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Archive for the ‘ASRM 2012’ Category

Long Island IVF and the ASRM 2012

By David Kreiner MD

November 5th, 2012 at 10:08 pm

Annually, reproductive endocrinologists and fertility experts from all over the world converge for information sharing and presentations of the most recent scientific advances in our field.  This year, the American Society for Reproductive Medicine (ASRM) meeting took place in San Diego, in a venue that was fertile ground for the growth and development of reproductive medicine.

Among the most exciting topics was the use of pre-implantation genetic screening (PGS) of embryos to improve IVF live birth rates and eliminate miscarriages.  Aneuploidy, the presence of chromosomally abnormal embryos, may be diagnosed through PGS with techniques that can analyze all 23 pairs of chromosomes.  One such method, aCGH (microarray comparative genomic hybridization), is available in most labs on day 3 cleaved biopsies as well as blastocyst biopsies.

The biopsied embryos can be determined to be euploid (chromosomally normal) or aneuploid.  Transfer then can be limited to only the euploid embryos which will eliminate most miscarriages and potentially improve the live birth rate.  This is especially useful in cases of repeat miscarriages and repeat implantation failures.

Whether to have the embryos biopsied on day 3 or day 5 depends on a few factors:

1-         Day 3 biopsy is a somewhat more invasive procedure with a higher rate of mosaicism (embryos containing multiple cell lines) leading to occasional false positive results.

2-         Day 5 biopsies are less likely to lead to fresh transfers.  Success is dependent on the survival of thawed frozen blastocysts.  The recommended form of blastocyst freezing is through vitrification.

Since most miscarriages are the result of implanted aneuploid embryos, we hypothesize that if we add PGS to an IVF protocol we can prevent most miscarriages.

In one study where PGS was performed as an adjunct to IVF/ICSI for patients with recurrent miscarriages (>2miscarriages), it was found that 53.7% of embryos studied were aneuploid in patients with a mean age of 37.5.  In 21.4% of all cases studied all the embryos from the IVF cycle were found to be aneuploid.

I recommend that you ask your physician whether PGS would be useful in your case.

 

 

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It’s ASRM Conference Time!

By Tracey Minella

October 19th, 2012 at 2:35 pm

credit: photographic 1980/freedigitalphotos.net

As we speak, Long Island IVF’s Drs. David Kreiner and Steven Brenner, along with other members of the LI IVF team, are heading to the airport, getting ready to board a flight to the annual American Society for Reproductive Medicine (ASRM) Conference in sunny San Diego.

It is the most anticipated conference of the year. Long Island IVF always sends representatives to the ASRM.  (Of course, others stay behind to take care of the patients.)

There’s a social mixer for this multi day event tomorrow. Opening ceremonies are on Sunday. This year’s theme is “Setting the Course for Reproductive Medicine.” It is the most popular and largest educational gathering of reproductive endocrinologists and related medical professionals in the country. Day after day, the team attends a series of seminars on the latest in cutting edge techniques and technologies. The evenings are for mingling socializing, meeting new friends and reconnecting with old ones. The final seminar is on Thursday.

Every year, there is at least one big “takeaway” to share. Sometimes there are several really promising developments. And as soon as the Long Island IVF team discovers it, we’ll be sharing it. Look for a wrap up post by Dr. Kreiner.

Want to learn more about what they’ll be discussing? Check out the ASRM conference details at: http://www.asrm.org/2012Schedule/

Do you have any questions about a particular topic on the schedule? Let us know.

On Twitter? Stay up-to-date with the #ASRM2012 hashtag.

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Do you think all practices should send representatives to conferences such as the ASRM to keep abreast of new developments in the field? Does your clinic participate?

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